P-glycoprotein (PGP) Table - the Effect of Drugs and Foods
This table is an abridged guide to PGPs. For an introduction to PGPs, click here. To appreciate the full benefits of this information, click here to get a free 30-day trial version of YouScript®. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.
|
Not Substrates |
Substrates |
Inhibitors |
NOT Inhibitors |
Inducers |
|
albendazole 11901088 |
actinomycin D 11497241 |
alfentanil 11964599 |
albendazole 11901088 |
?amitriptyline 10831014 |
|
alfentanil 11964599 |
aldosterone (Delph 2000) |
amiloride Watkins |
fluconazole 11751127 |
amprenavir Zhou 2008 |
|
amantadine 11602674 |
alpha-methyldigoxin 11284449 |
amiodarone 11231118 |
fluvastatin 17064205 |
ASA 11205285 |
|
bezafibrate 14698041 |
amiloride Watkins |
amitripyline 10408903 |
isosorbide 12499648 |
bromocriptine Zhou 2008 |
|
bupropion 18239278 |
amitriptyline Watkins 18239278 |
astemizole Zhou 2008 |
levetiracetam 9929511 |
chlorambucil Zhou 2008 |
|
chlorpheniramine 11602674 |
amoxicillin 2213563 |
atovaquone 11459198 (modest) |
pravastatin 11902809 |
cisplatin Zhou 2008 |
|
chlorpromazine 11602674 |
amprenavir 11242145 |
atorvastatin 11250868 |
zolpidem 12469329 |
clotrimazole 12489979 |
|
clozapine 10831014 |
atorvastatin 12406646 |
azelastine 11231118 |
|
colchicine Zhou 2008 |
|
cortexolone 12379510 |
beta-acetyldigoxin 11284449 |
azidopine Watkins |
|
cyclosporine Zhou 2008 |
|
fenbibrate 14698041 |
bisantrene 11497241 |
azithromycin 18027988 |
|
delavirdine 12180537 |
|
fentanyl 11964599 |
bunitrolol 12406646 |
bepidil Zhou 2008 |
|
daunorubicin Zhou 2008 |
|
fluconazole 11751127 |
carbamazepine 11733711 |
biricodar11895894++ |
|
dexamethasone 12451243 |
|
flunitrazepam 10831014 |
celiprolol 12406646 |
bromocriptine 11861816 |
|
doxorubicin 11311122 |
|
fluoxetine 10831014 |
cetirizine 16364611 |
carbamazepine 12954800 |
|
efavirenz 12180537 |
|
gemfribosil 14698041 |
chloroquine Watkins |
carvedilol 11895100 |
|
erythromycin Zhou 2008 |
|
haloperidol 10831014 |
chlorpromazine Watkins |
chloroquine Watkins |
|
etoposide Zhou 2008 |
|
itraconazole 11602674 |
cimetidine 9862768 |
chlorpromazine 11747345 |
|
flurouracil Zhou 2008 |
|
ketoconazole 11602674 |
citalopram 18239278 |
clarithromycin 10901387 |
|
hydroxyurea Zhou 2008 |
|
lidocaine 11602674 |
ciprofloxacin 9283689 |
cyclosporin 10586385++ |
|
insulin Zhou 2008 |
|
methotrexate 11602674 |
colchicine 11284688 |
cyproheptadine 11498864 |
|
lopinavir-chronic 12700464 |
|
midazolam 11602674 |
corticosteroids (Delph 2000) |
darunavir 18389894 |
|
methotrexate Zhou 2008 |
|
mirtazapine 8215618 |
cortisol 11966513 |
desethylamiodarone 11231118 |
|
mitoxantrone Zhou 2008 |
|
nifedipine 12406646 |
cyclosporine 11199931 |
desipramine 10408903 |
|
morphine Zhou 2008 |
|
ofloxacin |
dexamethasone 10831014 |
dexniguldipine 12021398 |
|
nefazodone 11452702, 12700464 |
|
?ranitidine 11602674 |
daunorubicin 11199931 |
dexrazoxane 11286477 |
|
nelfinavir Zhou 2008 |
|
sufentanil 11964599 |
debrisoquine 12406646 |
diltiazem 11497241 |
|
nevirapine 12180537 |
|
sumatriptan 11602674 |
dexamethasone 11199931 |
dipyridamole 11497241 |
|
nicardipine Zhou 2008 |
|
yohimbine 11602674 |
digoxin 11284449 |
disulfiram 14978246 |
|
nifedipine Zhou 2008 |
|
|
digitoxin 11284449 |
doxazosin 11895100 |
|
paclitaxel 12489979 |
|
|
diltiazem 11602674 |
elicridqr Zhou 2008 |
|
phenobarbital 12489979 |
|
|
dipyridamole 11602674 |
emetine 11743742 |
|
phenothiazines Watkins |
|
|
docetaxel 11497241 |
erythromycin 11322768 |
|
phenytoin Zhou 2008 |
|
|
domperidone 16364611 |
felodipine 10586385 |
|
prazosin Watkins |
|
|
doxepine 14550684 |
fenofibrate 14698041 |
|
probenecid Zhou 2008 |
|
|
doxorubicin 11286477, 17722645 |
fentanyl 11964599 |
|
reserpine 12489979 |
|
|
doxycycline Zhou 2008 |
flavonoids 11915946 |
|
retinoid acid Zhou 2008 |
|
|
emetine Watkins |
fluoxetine 12649369,18851896 |
|
ritonavir (chronic)11745741 |
|
|
enoxacin 10586385 |
fluphenazine 11199931, 11743742 |
|
rifampin 11297522 |
|
|
epirubicin 11497241 |
fluvoxamine 12649369 |
|
St. John's Wort 11739235 |
|
|
erythromycin 11199931 |
fucidin 11497241 |
|
tacrolimus Zhou 2008 |
|
|
estradiol 10586385 |
gallpamil 11743742 |
|
tamoxifen Zhou 2008 |
|
|
etoposide 11290874 |
glyburide 10087141 |
|
trazodone 11452702 |
|
|
fexofenadine 11240975 |
gramicidin D 11497241 |
|
verapamil Zhou 2008 |
|
|
glyburide 11406737 |
grapefruit juice 11231102 |
|
vinblastine Zhou 2008 |
|
|
gramicidin D 16364611 |
garlic 11466175 |
|
vincristine Zhou 2008 |
|
|
grepafloxacin 11861816 |
green t ea (catechins) 11853888 |
|
yohimbine Zhou 2008 |
|
|
hydrocortisone (10586385 ) |
haloperidol 10408903,17331325 |
|
|
|
|
imatinib 18449471 |
hydrocortisone 10586385 |
|
|
|
|
indinavir 11242145 |
hyroxyzine 11290874 |
|
|
|
|
irinotecan 11489791 |
josamycin 10901387 |
|
|
|
|
itraconazole 16364611 |
ketoconazole 11199931 |
|
|
|
|
ivermectin 18468555 |
imipramine 10408903 |
|
|
|
|
ketoconazole 16364611 |
itraconazole 10586385 |
|
|
|
|
LAAM 17690563 |
ivermectin Watkins |
|
|
|
|
L-dopa Watkins |
ketoconazole Zhou 2008 |
|
|
|
|
lansoprazole 11770010 |
laniquidar Thomas H ++ |
|
|
|
|
levofloxacin 12406646 |
lansoprazole 11770010 |
|
|
|
|
loperamide 11199931 |
levothyroxin 12235446 |
|
|
|
|
lopinavir 16364611 |
lidocaine 10586385 |
|
|
|
|
losartan 12406646 |
loperamide 11964599 |
|
|
|
|
lovastatin (Delph 2000) |
lopinavir-acute 12700464, 12700464 |
|
|
|
|
maraviroc FDA 2008 meetings |
loratadine 11454724 |
|
|
|
|
methylprednisolone 12535574 |
lovastatin 11250868 |
|
|
|
|
mibefradil 10901697 |
maprotiline 10408903 |
|
|
|
|
mithramycin 12406646 |
mefloquine 11497241 |
|
|
|
|
mitomycin C 17722645 |
methadone 11408360 |
|
|
|
|
mitoxantrone 11497241 |
mibefradil 10901697 |
|
|
|
|
morphine 11964599 |
midazolam (Delph 2000) |
|
|
|
|
nelfinavir 17591677 |
mitomycin C 11311122 |
|
|
|
|
nicardipine 18624680 |
nefazodone (acute) 11452702 |
|
|
|
|
nifedipine 18624680 |
nelfinavir (Delph 2000) |
|
|
|
|
nizatidine 19319690 |
nicardipine 16364611 |
|
|
|
|
nortriptyline 12082591 |
nitrendipine Zhou 2008 |
|
|
|
|
olanazpine 18239278 |
nobilitin 11743742 |
|
|
|
|
ondansetron 11199931 |
norverapamil 11743742 |
|
|
|
|
paclitaxel 11199931, 17722645 |
omeprazole 11770010 |
|
|
|
|
paroxetine 17304149 |
orange juice-Seville 12095536 |
|
|
|
|
pentazocaine Zhou 2008 |
ofloxacin 11322768 |
|
|
|
|
phenobarbital Zhou 2008 |
paroxetine 12649369 |
|
|
|
|
phenytoin 11908747 |
pantoprazole 11770010 |
|
|
|
|
prednisolone 12379510 |
phenothiazines 11282269 |
|
|
|
|
progesterone 18624680 |
piperine 12130727 |
|
|
|
|
puromycin Watkins |
pimozide 11497241 |
|
|
|
|
quetiapine 12031686 |
probenecid 11322768 |
|
|
|
|
quinidine 12406646 |
progesterone 10586385 |
|
|
|
|
ranitidine 9862768 |
promethazine 11497241 |
|
|
|
|
rapamycin 10586385 |
propafenone 11497241 |
|
|
|
|
rifampin (Delph 2000) |
propranolol 11199931 |
|
|
|
|
risperidone 17337319 |
quercetin 12427482 |
|
|
|
|
ritonavir 11242145 |
quinacrine 16364611 |
|
|
|
|
saquinavir 17722645 |
quinidine 11199931 |
|
|
|
|
sertraline 18239278 |
quinine 11497241 |
|
|
|
|
sirolimus Zhou 2008 |
reserpine 11497241, 11743742 |
|
|
|
|
sparfloxacin 12406646 |
ritonavir (initial)10831014 |
|
|
|
|
tacrolimus 11303042 |
saquinavir 17365284 |
|
|
|
|
talinolol 11231102 |
sertraline 12649369 |
|
|
|
|
tamoxifen 17526937 |
simvastatin 11250868 |
|
|
|
|
taxol 9531522 |
spironolactone 11497241 |
|
|
|
|
teniposide 11497241, 17722645 |
sufentanil 11964599 |
|
|
|
|
terfenadine 11697207 |
tacrolimus Zhou 2008 |
|
|
|
|
tetracycline Zhou 2008 |
tamoxifen 10586385 ++ |
|
|
|
|
topiramate 12609264 |
tariquidar Thomas H++ |
|
|
|
|
topotecan 11497241, 17975156 |
telithromycin 18027988 |
|
|
|
|
triamcinolone 16364611 |
terfenadine 10586385 |
|
|
|
|
trimipramine 18239278 |
testosterone Watkins |
|
|
|
|
valinomycin 17722645 |
tetrabenzine Zhou 2008 |
|
|
|
|
valspodar Zhou 2008 |
thioridazine 7924890 |
|
|
|
|
vecuronium Zhou 2008 |
trifluoperazine 11497241 |
|
|
|
|
venlafaxine 16387324 |
trifluopromazine 11497241 |
|
|
|
|
verapamil 12535574 |
trimipramine 10408903 |
|
|
|
|
vinblastine 11303953 |
valinomycin 11497241, 11743742 |
|
|
|
|
vincristine 10586385 |
vanadate 12535574 |
|
|
|
|
vindesine 10586385 |
(venlafaxine) 12649369 |
|
|
|
|
vinorelbine 11497241 |
verapamil 11199931++ |
|
|
|
|
FK506 |
vinblastine 10586385 |
|
|
|
|
|
FK506 10586385 |
|
|
|
|
|
RU486(mifepristone) 10586385 |
|
|
|
|
|
Valspodar PSC 833 11249778++ |
|
|
|
|
|
zosuquidar Thomas H ++ |
|
|
|
|
|
2n-propylquinoline 12810046 |
|
|