P-glycoprotein (PGP) Table - the Effect of Drugs and Foods

This table is an abridged guide to PGPs. For an introduction to PGPs, click here. To appreciate the full benefits of this information, click here to get a free 30-day trial version of YouScript®. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Not Substrates

Substrates

Inhibitors

NOT Inhibitors

Inducers

albendazole  11901088

actinomycin D 11497241

alfentanil 11964599

albendazole  11901088

?amitriptyline  10831014

alfentanil 11964599

aldosterone (Delph 2000)

amiloride Watkins

fluconazole 11751127

amprenavir Zhou 2008

amantadine 11602674

alpha-methyldigoxin  11284449

amiodarone 11231118

fluvastatin 17064205

ASA 11205285

bezafibrate 14698041

amiloride Watkins

amitripyline 10408903

isosorbide 12499648

bromocriptine Zhou 2008

bupropion 18239278

amitriptyline Watkins 18239278

astemizole Zhou 2008

levetiracetam 9929511

chlorambucil Zhou 2008

chlorpheniramine 11602674

amoxicillin 2213563

atovaquone 11459198 (modest)

pravastatin 11902809

cisplatin Zhou 2008

chlorpromazine 11602674

amprenavir  11242145

atorvastatin 11250868

zolpidem 12469329

clotrimazole 12489979

clozapine  10831014

atorvastatin 12406646

azelastine 11231118

 

colchicine Zhou 2008

cortexolone  12379510

beta-acetyldigoxin 11284449

azidopine Watkins

 

cyclosporine Zhou 2008

fenbibrate 14698041

bisantrene 11497241

azithromycin 18027988

 

delavirdine  12180537

fentanyl 11964599

bunitrolol 12406646

bepidil Zhou 2008

 

daunorubicin Zhou 2008

fluconazole 11751127

carbamazepine 11733711

biricodar11895894++

 

dexamethasone 12451243

flunitrazepam  10831014

celiprolol  12406646

bromocriptine 11861816

 

doxorubicin 11311122

fluoxetine  10831014

cetirizine 16364611

carbamazepine 12954800

 

efavirenz 12180537

gemfribosil 14698041

chloroquine Watkins

carvedilol 11895100

 

erythromycin Zhou 2008

haloperidol  10831014

chlorpromazine Watkins

chloroquine Watkins

 

etoposide Zhou 2008

itraconazole 11602674

cimetidine  9862768

chlorpromazine  11747345

 

flurouracil Zhou 2008

ketoconazole 11602674

citalopram 18239278

clarithromycin 10901387

 

hydroxyurea Zhou 2008

lidocaine 11602674

ciprofloxacin 9283689

cyclosporin 10586385++

 

insulin Zhou 2008

methotrexate 11602674

colchicine 11284688

cyproheptadine 11498864

 

lopinavir-chronic  12700464

midazolam 11602674

corticosteroids (Delph 2000)

darunavir 18389894

 

methotrexate Zhou 2008

mirtazapine 8215618

cortisol 11966513

desethylamiodarone 11231118

 

mitoxantrone Zhou 2008

nifedipine 12406646

cyclosporine 11199931

desipramine  10408903 

 

morphine Zhou 2008

ofloxacin

dexamethasone  10831014

dexniguldipine 12021398

 

nefazodone 11452702, 12700464

?ranitidine 11602674

daunorubicin 11199931

dexrazoxane  11286477

 

nelfinavir Zhou 2008

sufentanil 11964599

debrisoquine 12406646

diltiazem 11497241

 

nevirapine  12180537

sumatriptan 11602674

dexamethasone 11199931

dipyridamole  11497241

 

nicardipine Zhou 2008

yohimbine 11602674

digoxin 11284449

disulfiram 14978246

 

nifedipine Zhou 2008

 

digitoxin  11284449

doxazosin 11895100

 

paclitaxel 12489979

 

diltiazem 11602674

elicridqr Zhou 2008

 

phenobarbital 12489979

 

dipyridamole 11602674

emetine 11743742

 

phenothiazines Watkins

 

docetaxel 11497241

erythromycin  11322768

 

phenytoin Zhou 2008

 

domperidone 16364611

felodipine 10586385

 

prazosin Watkins

 

doxepine 14550684

fenofibrate 14698041

 

probenecid Zhou 2008

 

doxorubicin 11286477, 17722645

fentanyl 11964599

 

reserpine 12489979

 

doxycycline Zhou 2008

flavonoids 11915946

 

retinoid acid Zhou 2008

 

emetine Watkins

fluoxetine  12649369,18851896

 

ritonavir (chronic)11745741

 

enoxacin 10586385

fluphenazine 11199931, 11743742

 

rifampin  11297522

 

epirubicin 11497241

fluvoxamine  12649369

 

St. John's Wort 11739235

 

erythromycin 11199931

fucidin 11497241

 

tacrolimus Zhou 2008

 

estradiol 10586385

gallpamil 11743742

 

tamoxifen Zhou 2008

 

etoposide  11290874

glyburide 10087141

 

trazodone 11452702

 

fexofenadine 11240975

gramicidin D 11497241

 

verapamil Zhou 2008

 

glyburide 11406737

grapefruit juice 11231102

 

vinblastine Zhou 2008

 

gramicidin D 16364611

garlic 11466175

 

vincristine Zhou 2008

 

grepafloxacin 11861816

green t ea (catechins) 11853888

 

yohimbine Zhou 2008

 

hydrocortisone (10586385 )

haloperidol  10408903,17331325

 

 

 

imatinib 18449471

hydrocortisone 10586385

 

 

 

indinavir  11242145

hyroxyzine 11290874

 

 

 

irinotecan 11489791

josamycin 10901387

 

 

 

itraconazole 16364611

ketoconazole 11199931

 

 

 

ivermectin 18468555

imipramine  10408903

 

 

 

ketoconazole 16364611

itraconazole 10586385

 

 

 

LAAM 17690563

ivermectin Watkins

 

 

 

L-dopa Watkins

ketoconazole Zhou 2008

 

 

 

lansoprazole 11770010

laniquidar Thomas H ++

 

 

 

levofloxacin 12406646

lansoprazole 11770010

 

 

 

loperamide 11199931

levothyroxin 12235446

 

 

 

lopinavir  16364611

lidocaine 10586385

 

 

 

losartan 12406646

loperamide 11964599

 

 

 

lovastatin (Delph 2000)

lopinavir-acute  12700464, 12700464 

 

 

 

maraviroc FDA 2008 meetings

loratadine  11454724

 

 

 

methylprednisolone 12535574

lovastatin 11250868

 

 

 

mibefradil 10901697

maprotiline  10408903

 

 

 

mithramycin 12406646

mefloquine 11497241

 

 

 

mitomycin C 17722645

methadone 11408360

 

 

 

mitoxantrone 11497241

mibefradil 10901697

 

 

 

morphine 11964599

midazolam (Delph 2000)

 

 

 

nelfinavir 17591677

mitomycin C 11311122

 

 

 

nicardipine 18624680

nefazodone (acute)  11452702

 

 

 

nifedipine 18624680

nelfinavir (Delph 2000)

 

 

 

nizatidine 19319690

nicardipine 16364611

 

 

 

nortriptyline 12082591

nitrendipine Zhou 2008

 

 

 

olanazpine 18239278

nobilitin 11743742

 

 

 

ondansetron 11199931

norverapamil 11743742

 

 

 

paclitaxel 11199931, 17722645

omeprazole 11770010

 

 

 

paroxetine 17304149

orange juice-Seville 12095536

 

 

 

pentazocaine Zhou 2008

ofloxacin  11322768

 

 

 

phenobarbital Zhou 2008

paroxetine  12649369

 

 

 

phenytoin 11908747

pantoprazole 11770010

 

 

 

prednisolone  12379510

phenothiazines 11282269

 

 

 

progesterone 18624680

piperine 12130727

 

 

 

puromycin Watkins

pimozide  11497241

 

 

 

quetiapine 12031686

probenecid  11322768

 

 

 

quinidine 12406646

progesterone 10586385

 

 

 

ranitidine  9862768

promethazine  11497241

 

 

 

rapamycin 10586385

propafenone  11497241

 

 

 

rifampin (Delph 2000)

propranolol 11199931

 

 

 

risperidone 17337319

quercetin 12427482

 

 

 

ritonavir  11242145

quinacrine 16364611

 

 

 

saquinavir 17722645

quinidine 11199931

 

 

 

sertraline 18239278

quinine 11497241

 

 

 

sirolimus Zhou 2008

reserpine  11497241, 11743742

 

 

 

sparfloxacin 12406646

ritonavir (initial)10831014

 

 

 

tacrolimus  11303042

saquinavir 17365284

 

 

 

talinolol 11231102

sertraline 12649369

 

 

 

tamoxifen 17526937

simvastatin  11250868

 

 

 

taxol 9531522

spironolactone  11497241

 

 

 

teniposide 11497241, 17722645

sufentanil 11964599

 

 

 

terfenadine 11697207

tacrolimus Zhou 2008

 

 

 

tetracycline Zhou 2008

tamoxifen 10586385 ++

 

 

 

topiramate 12609264

tariquidar  Thomas H++

 

 

 

topotecan 11497241, 17975156

telithromycin 18027988

 

 

 

triamcinolone 16364611

terfenadine 10586385

 

 

 

trimipramine 18239278

testosterone Watkins

 

 

 

valinomycin 17722645

tetrabenzine Zhou 2008

 

 

 

valspodar Zhou 2008

thioridazine  7924890

 

 

 

vecuronium Zhou 2008

trifluoperazine  11497241

 

 

 

venlafaxine 16387324

trifluopromazine 11497241

 

 

 

verapamil 12535574

trimipramine  10408903

 

 

 

vinblastine  11303953

valinomycin  11497241, 11743742

 

 

 

vincristine 10586385

vanadate 12535574

 

 

 

vindesine 10586385

(venlafaxine)  12649369

 

 

 

vinorelbine  11497241

verapamil 11199931++

 

 

 

FK506

vinblastine 10586385

 

 

 

 

FK506 10586385

 

 

 

 

RU486(mifepristone) 10586385

 

 

 

 

Valspodar PSC 833 11249778++

 

 

 

 

zosuquidar Thomas H ++

 

 

 

 

2n-propylquinoline 12810046