Are you taking or considering medication to treat or prevent pain?

Are you taking additional medications?

Personalized medication management, including DNA testing, is extremely important for the proper management of pain because finding the right drug and dose is so vitally important. This is not surprising to people who study genetics. Research shows that of all the clinical factors that alter a patient’s response to drugs (such as age, sex, weight, general health and liver function), genetic factors account for a significant proportion.

At the 23rd Annual Meeting of the American Academy of Pain Medicine, a presentation on the clinical effect of genotyping chronic pain patients revealed:

  • 80% of patients reporting ADRs were shown to have poor CYP2D6 metabolism
  • Some methadone patients seeking higher doses were Ultra Metabolizers: proof that they were not exhibiting drug-seeking behavior

Many common pain medications require activation by an enzyme called CYP2D6 to become effective. Approximately half of patients have genes that alter the function of 2D6. Testing for these gene alterations allows for alteration of dosage regimens to compensate for altered metabolism and optimize the safety and efficacy of the opioid family of analgesics. Without knowing your genetics, your physician may need to go through months of trial-and-error prescribing to find the right drug and dose for you.

Population Frequency of Cytochrome P450 (CYP) Metabolizer Types

(no or low enzyme levels)
Intermediate (reduced enzyme levels) Extensive (normal enzyme levels) Ultra-Extensive (high enzyme levels)
CYP2D6 10% 35% 48% 7%

Now your healthcare provider can help optimize your response to pain drugs and many other medications by ordering DNA testing. Your results will be entered into our personalized medication management software, YouScript. You or your healthcare providers can log in to see if current or future medications are predicted to cause drug-drug or drug-gene interactions so dosage and selection can be catered to your needs. You receive a 90-day subscription free with your testing; additional one year extensions are available for a nominal fee. Of course, your DNA never changes so the testing only needs to be done once in a lifetime.

Click here to view a list of drugs for which DNA testing may be helpful.

The Testing Process

The process is simple. You can order testing directly if you have a physician prescription or your healthcare provider can request testing for you. We send a cheek swab collection kit with directions by mail. Samples are submitted using the enclosed return mailer and results are provided in 5-7 days. Call a DNA testing consultant at 800-TEST-DNA (800-837-8362) for details and to order.

YouScript is typically covered by Medicare and most private insurers.

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  1. YouScript is available with a prescription from your doctor, and most insurance plans cover the cost.

  2. 1

    Ask your doctor to complete the prescription form and to call 800 TEST-DNA (800-837-8362) for a collection kit.

  3. 2

    Submit a cheek swab sample for DNA testing using the provided kit.

  4. 3

    Review the results with your doctor. The report will aid your doctor in making decisions about altering the dosage or form of drugs prescribed to you to prevent treatment failures and adverse drug reactions.

Take the First Step