Genetic Variations in Cytochromes Affect
Drug Metabolism

More than 85% of patients have significant genetic variations in the most important cytochromes - CYP2D6, CYP2C9, CYP2C19, CYP3A4 and CYP3A5. The YouScript Personalized Prescribing System includes testing of these cytochromes or CYPs which are responisble for metabolizing the majority of commonly prescribed medications.

Gene

Poor
Metabolizer

Intermediate
Metabolizer

Normal
Metabolizer

Rapid or
Ultrarapid
Metabolizer

CYP2D6

10%

35%

48%

7%

CYP2C9

2-4%

>35%

~60%

N/A

CYP2C19*

2-20%

24-36%

14-44%

30%

*CYP2C19 variability depends on ethnicity.

 

  Ethnicity
Gene Variant Activity Caucasian Asian African
CYP3A4 Decreased 5.3% 0% 0%
CYP3A5 Decreased 93% 75% 27-50%

 

Once tested, each patient is classified as a Poor, Intermediate, Normal, Rapid, or Ultra Rapid Metabolizer. These classifications describe a patient’s inherent drug metabolizing capacity, a major contributor to adverse events. This simplified chart describes effects that may be seen in patients with each of the phenotypes.

 

*Prodrugs must be metabolized in order to become active.

Until recently, you had little choice but to try medications without knowing in advance how patients might genetically respond. But no more: with personalized prescribing by YouScript, you’ll know upfront what medications will likely prove the most effective for your patient – and which ones will not. And you’ll know how medications will interact with the prescriptions and supplements she’s already taking.

YouScript is typically covered by Medicare and most private insurers.

Call 800-TEST-DNA to ask how it works. There is no cost to you and supplies will be sent out immediately. Pharmacists and other support staff are here to help whenever you have questions.

Youscript Video


YouScript Personalized Prescribing System

How to Request
YouScript

  1. 1

    Sign up online, ask your YouScript consultant, or call 800-TEST-DNA (800-837-8362).

  2. 2

    Receive your free YouScript test kits and supplies. Alternatively, we can ship the kit directly to a patient if you complete and fax a prescription to 206-219-4000.

  3. 3

    Collect a buccal swab or blood sample from your patient and ship it in a prepaid mailer.

Take the First Step