CYP (Cytochrome P450) Variability Table

This table is an abridged guide to Cytochrome variability. To appreciate the full benefits of this information, click here to get a free 30-day trial version of YouScript^®. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

Characteristic		1A2	2A6	2B6	2C9	2C19	2D6	2E1	3A
Percent of Total CYPs		10-15%	4%	1-10%%	15-20%	5%	2.5%	7%	30-40%
Inter-individual Variability		40 fold	30 fold	50 fold	25-100 fold		2.5 fold	7 fold	40 fold
Common Polymorhphism		1A2*1F			2C9*2	2C19*2	2D6*2
		1A2*1C			2C9*3	2C19*3	2D6*4
					2C9*5	2C19*4	2D6*5
						2C19*5	2D6*10
						2C19*17	2D6*17
							2D6*41
Slow Metabolizers
	Caucasians		20%		18%	2-4%	7-10%
	African Americans		2%		1%	1%	6-8%
	Asians				1%		1-2%
	Japanese				1%	18-23%
	Chinese					5-17%
Ultrafast Metabolizers
	Caucasians						1%
	Asians						1%
	Swedes					18%
	Chineses					4%
Decreases with Age		Same as adult or dec	?	?	Dec	Dec	No	Conflictual results	Same as adult or dec
Gender male/female		Higher men			Equal	Equal	Equal	Slightly higher men with some drugs ? effect on hepatic blood flow	Slightly higher women