Changes in Clearance During Pregnancy for some CYPs and UGTs
This table is an abridged guide to CYPs and UGTs during pregnancy. To appreciate the full benefits of this information, click here to get a free 30-day trial version of YouScript®. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.
Changes in Clearance
| 1st semester | 2nd semester | 3rd semester | |
| CYP 1A2 | reduced 33% | reduced 49% | reduced 65% |
| CYP2A6 | increased 54% | increased 54% | |
| CYP2B6 | |||
| CYP2C8 | |||
| CYP2C9 | no change | no change | increased 20% |
| CYP2C19 | reduced 50% | reduced 50% | |
| CYP2D6 | increased 26% | increased 35% | increased 48% |
| CYP2E1 | |||
| CYP3A4 | increased 35-38% | increased 35-38% | increased 35-38% |
| UGT1A4 | increased 200% | increased 200% | increased 300% |
| UGT2B7 | indeterminate | ||
| acetylation | indeterminate | no change | no change |
| xanthin oxidase | no change | no change | no change |