CYP and UGT Metabolic Route Development in Childhood
This table is an abridged guide to CYP and UGT metabolic route development in childhood. To appreciate the full benefits of this information, click here to get a free 30-day trial version of YouScript®. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.
Changes in Clearance
Metabolic Route |
Fetus |
Development in Childhood |
| CYP1A2 | becomes active after the 4th or 5th month after birth; formula feeding accelerate maturation | |
| CYP2A6 | ||
| CYP2B6 | ||
| CYP2C8 | ||
| CYP2C9 | becomes active in first few weeks after birth;50% reach adult values by 5 months;exceeds adult activity from 3-10 years; reaches adult values after puberty | |
| CYP2C19 | becomes active in first few weeks after birth; reaches adult values about 10 years | |
| CYP2D6 | becomes active first few weeks after birth;reaches adult values by 10 years | |
| CYP2E1 | gradually develops over first few months after birth | |
| CYP3A4 | appears in first few weeks after birth; may be lower activity from 5-15 years; formula feeding accelerates maturation | |
| CYP3A5 | present | present in 20% of population |
| CYP3A7 | predominant CYP | fades after 2 weeks post natal, then present in 20% population |
| acetylation | reaches adult levles by 2-4 years | |
| sulfation | predominant Phase 2 | reaches adult levels by 2-4 years |
| UGT1A1 | immature at birth, responsible for hyperbilirubinemia; reaches adult values 3-6 months after birth | |
| UGT2B7 | immature at birth; reaches adult values 3-6 months after birth | |
| UGT1A9 | develops only after second year after birth | |
| UGT2B4 | develops only after second year after birth | |
| Reference | PubMed PMID:17065585 |