UDP glucuronosyltransferase (UGT) Reference Table

This table is an abridged guide to UGTs. To appreciate the full benefits of this information, click here to get a free 30-day trial version of YouScript^®. This metabolism-based drug interaction software predicts response to medication combinations with optional input of genetic variations.

	UGT1A1	UGT1A3	UGT1A4	UGT1A6	UGT1A9	UGT2B7	UGT2B15
Chromosome	2	2	2	2	2	4	4
Genetic Variation	yes	yes	yes	yes	yes	yes	yes
Some Endogenous Substrates	bilirubin	estrones	androsterone	serotonin	thyroxine	androsterone	dihydro- testosterone
	estriol		progestins			bile acid
Some Substrate Drugs	acetaminophen	buprenorphine	(amitriptyline)	acetaminophen	acetaminophen	carbamazepine	desloratadine
	buprenorphine	(chlorpromazine)	chlorpromazine	phenytoin	ethinyl estradiol	ibuprofen	s-oxazepam
	ethinyl estradiol	(clozapine)	clomipramine	valproate	ibuprofen	lamotrigine	s-lorazepam
	ibuprofen	cyproheptadine	clozapine		phenytoin	lorazepam
	irinotecan mb-SN-38	diphenydramine	cyproheptadine		valproate	morphines
	nicotine	doxepin	diphenydramine		warfarin	propranolol
	phenytoin	(ibuprofen)	doxepin			sertraline
	warfarin	(valproate)	imipramine			valproate
			lamotirigne			zidovudine
			loxapine
			olanzapine
			phenytoin
			trifluoperazine
Possible Inducers	dexamethasone		carbamazepine	dexamethasone	phenobarbital	phenobarbital
	phenobarbital		ethinyl estradiol			phenytoin
	phenytoin		(oxcarbamazepine)			rifampin
			phenobarbital
			phenytoin
			rifampin
Possible Inhibitors	ketoconazole	imipramine	probenecid	probenecid	probenecid	codeine	ibuprofen
	probenecid	probenecid			ketoconazole	diazepam	ketoconazole
					valproate	ketoconazole	probenecid
						morphine	valproate
						probenecid
						valproate